Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models
dc.contributor.author | Lee, Jue Er Amanda | |
dc.contributor.author | Mitchell, Naomi | |
dc.contributor.author | Zaytseva, Olga | |
dc.contributor.author | Chahal, Arjun | |
dc.contributor.author | Mendis, Peter | |
dc.contributor.author | Cartier-Michaud, Amandine | |
dc.contributor.author | Parsons, Linda M. | |
dc.contributor.author | Poortinga, Gretchen | |
dc.contributor.author | Levens, David | |
dc.contributor.author | Hannan, Ross | |
dc.contributor.author | Quinn, Leonie | |
dc.date.accessioned | 2018-11-29T22:56:34Z | |
dc.date.available | 2018-11-29T22:56:34Z | |
dc.date.issued | 2015 | |
dc.date.updated | 2018-11-29T08:13:02Z | |
dc.description.abstract | Nucleotide excision DNA repair (NER) pathway mutations cause neurodegenerative and progeroid disorders (xeroderma pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD)), which are inexplicably associated with (XP) or without (CS/TTD) cancer. Moreover, cancer progression occurs in certain patients, but not others, with similar C-terminal mutations in the XPB helicase subunit of transcription and NER factor TFIIH. Mechanisms driving overproliferation and, therefore, cancer associated with XPB mutations are currently unknown. Here using Drosophila models, we provide evidence that C-terminally truncated Hay/XPB alleles enhance overgrowth dependent on reduced abundance of RNA recognition motif protein Hfp/FIR, which transcriptionally represses the MYC oncogene homologue, dMYC. The data demonstrate that dMYC repression and dMYC-dependent overgrowth in the Hfp hypomorph is further impaired in the C-terminal Hay/XPB mutant background. Thus, we predict defective transcriptional repression of MYC by the Hfp orthologue, FIR, might provide one mechanism for cancer progression in XP/CS | |
dc.format.mimetype | application/pdf | en_AU |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/1885/153564 | |
dc.provenance | © 2015 Macmillan Publishers Limited. http://www.sherpa.ac.uk/romeo/issn/2041-1723/..."Publisher's version/PDF may be used. On author's personal website, institutional repository or open access repository" from SHERPA/RoMEO site (as at 2/02/16). | |
dc.publisher | Macmillan Publishers Ltd | |
dc.source | Nature Communications | |
dc.title | Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models | |
dc.type | Journal article | |
dcterms.accessRights | Open Access | en_AU |
local.bibliographicCitation.issue | 15 | |
local.bibliographicCitation.startpage | 7404 | |
local.contributor.affiliation | Lee, Jue Er Amanda, University of Melbourne | |
local.contributor.affiliation | Mitchell, Naomi, University of Melbourne | |
local.contributor.affiliation | Zaytseva, Olga, University of Melbourne | |
local.contributor.affiliation | Chahal, Arjun, The University of Melbourne | |
local.contributor.affiliation | Mendis, Peter, University of Melbourne | |
local.contributor.affiliation | Cartier-Michaud, Amandine, Aix-Marseille University | |
local.contributor.affiliation | Parsons, Linda M., University of Melbourne | |
local.contributor.affiliation | Poortinga, Gretchen, Peter MacCallum Cancer Centre | |
local.contributor.affiliation | Levens, David, National Cancer Institute | |
local.contributor.affiliation | Hannan, Ross, College of Health and Medicine, ANU | |
local.contributor.affiliation | Quinn, Leonie, College of Health and Medicine, ANU | |
local.contributor.authoremail | u1000203@anu.edu.au | |
local.contributor.authoruid | Hannan, Ross, u1000203 | |
local.contributor.authoruid | Quinn, Leonie, u1037504 | |
local.description.notes | Imported from ARIES | |
local.identifier.absfor | 110999 - Neurosciences not elsewhere classified | |
local.identifier.ariespublication | u5192707xPUB10 | |
local.identifier.ariespublication | U3488905xPUB6746 | |
local.identifier.citationvolume | 6 | |
local.identifier.doi | 10.1038/ncomms8404 | |
local.identifier.scopusID | 2-s2.0-84935874480 | |
local.identifier.thomsonID | 000357175700006 | |
local.identifier.uidSubmittedBy | u5192707 | |
local.type.status | Published Version |
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