A pilot randomised controlled trial of modafinil during acute methamphetamine withdrawal: Feasibility, tolerability and clinical outcomes
dc.contributor.author | Lee, Nicole | |
dc.contributor.author | Pennay, Amy | |
dc.contributor.author | Hester, Robert | |
dc.contributor.author | McKetin, Rebecca | |
dc.contributor.author | Nielsen, Suzi | |
dc.contributor.author | Ferris, Jason | |
dc.date.accessioned | 2015-12-10T21:53:52Z | |
dc.date.issued | 2013 | |
dc.date.updated | 2016-02-24T10:33:29Z | |
dc.description.abstract | Introduction and Aims: There are no medications approved for the treatment of methamphetamine withdrawal. Wake-promoting agent modafinil has recently been proposed as a viable option. This paper reports on the results of a pilot study that tested the feasibility of modafinil in an inpatient withdrawal setting during acute methamphetamine withdrawal. Design and Methods: In a double-blind, randomised, placebo-controlled study, 19 methamphetamine dependent participants received modafinil (n=9) or placebo (n=10) daily for 7days (200mg for the first 5days and 100mg on days 6 and 7). Primary outcomes were retention in treatment and severity of withdrawal symptoms. Secondary outcomes were methamphetamine craving, sleep and physiological outcomes. Results: There were no significant differences between groups on retention in treatment, withdrawal severity, craving, sleep or physiological outcomes. There were no adverse events or side-effects reported. Conclusions: Modafinil was found to be tolerable and well accepted by methamphetamine users and feasible for short-term inpatient withdrawal, but the sample was too small to detect treatment effects. Larger trials are needed to establish efficacy. | |
dc.identifier.issn | 0959-5236 | |
dc.identifier.uri | http://hdl.handle.net/1885/38691 | |
dc.publisher | Carfax Publishing, Taylor & Francis Group | |
dc.source | Drug and Alcohol Review | |
dc.subject | Keywords: Methamphetamine; Modafinil; Randomised controlled trial; Withdrawal | |
dc.title | A pilot randomised controlled trial of modafinil during acute methamphetamine withdrawal: Feasibility, tolerability and clinical outcomes | |
dc.type | Journal article | |
local.bibliographicCitation.lastpage | 95 | |
local.bibliographicCitation.startpage | 88 | |
local.contributor.affiliation | Lee, Nicole, Flinders University | |
local.contributor.affiliation | Pennay, Amy, Curtin University | |
local.contributor.affiliation | Hester, Robert, University of Melbourne | |
local.contributor.affiliation | McKetin, Rebecca, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Nielsen, Suzi, Turning Point Alcohol and Drug Centre | |
local.contributor.affiliation | Ferris, Jason, Turning Point Alcohol and Drug Centre | |
local.contributor.authoremail | u5065925@anu.edu.au | |
local.contributor.authoruid | McKetin, Rebecca, u5065925 | |
local.description.embargo | 2037-12-31 | |
local.description.notes | Imported from ARIES | |
local.identifier.absfor | 111714 - Mental Health | |
local.identifier.absseo | 970111 - Expanding Knowledge in the Medical and Health Sciences | |
local.identifier.ariespublication | u4056230xPUB165 | |
local.identifier.citationvolume | 32 | |
local.identifier.doi | 10.1111/j.1465-3362.2012.00473.x | |
local.identifier.scopusID | 2-s2.0-84872288283 | |
local.identifier.thomsonID | 000313518300015 | |
local.identifier.uidSubmittedBy | u4056230 | |
local.type.status | Published Version |
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