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Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling

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Date

2006

Authors

Nolan, Christopher
Leahy, J L
Delghingaro-Augusto, Viviane
Moibi, J
Soni, K
Peyot, Marie-Line
Fortier, M
Guay, C
Lamontagne, Julien
Barbeau, Annie

Journal Title

Journal ISSN

Volume Title

Publisher

Springer

Abstract

Aims/hypothesis: The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance

Description

Keywords

Keywords: cyclic AMP; enzyme inhibitor; fatty acid; forskolin; glucagon like peptide 1; glucose; incretin; insulin; lipid; palmitic acid; tetrahydrolipstatin; triacylglycerol; triacylglycerol lipase; animal cell; animal experiment; animal model; article; cell funct Fatty acid partitioning; Fatty acid signalling; Glucagon-like peptide 1; Insulin resistance; Insulin secretion; Islet beta cell compensation; Lipolysis; Triglyceride-fatty acid cycling; Zucker fatty rat

Citation

URI

http://hdl.handle.net/1885/32239

Collections

ANU Research Publications

Source

Diabetologia

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1007/s00125-006-0305-5

Restricted until

2037-12-31

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01_Nolan_Beta_cell_compensation_for_2006.pdf (489.93 KB)

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