Buprenorphine dosing regime in the management of out-patient heroin withdrawal
| dc.contributor.author | Lintzeris, Nicholas | |
| dc.date.accessioned | 2015-12-13T23:05:46Z | |
| dc.date.issued | 2002 | |
| dc.date.updated | 2015-12-12T08:02:11Z | |
| dc.description.abstract | This study aimed to establish a buprenorphine regime suitable for the short-term management of out-patient heroin withdrawal using an open-label, single-group case series. Eighteen dependent injecting heroin users underwent an 8-day withdrawal episode with supervised dosing of sublingual Subutexr tablets. Buprenorphine doses were titrated daily over a 5-day period. Fifteen subjects (83%) completed the 5-day regime, and 14 (78%) completed the 8-day withdrawal episode. The mean doses ((SD) were 6.1 (1.2) mg on day 1; 9.6 (1.7) mg on day 2; 10.1 (1.9) mg on day 3; 8.9 (2.0) mg on day 4; 4.1 (1.5) mg on day 5; and a total regime dose of 38. 9 (5. 8) mg. Withdrawal severity was mild, with minimal rebound upon the cessation of dosing. Five subjects reported no heroin use, and five subjects reported using on only one occasion during the 8 days. An out-patient buprenorphine regime is recommended. | |
| dc.identifier.issn | 0959-5236 | |
| dc.identifier.uri | http://hdl.handle.net/1885/85695 | |
| dc.publisher | Carfax Publishing, Taylor & Francis Group | |
| dc.source | Drug and Alcohol Review | |
| dc.subject | Keywords: buprenorphine; adult; ambulatory care; article; drug administration; female; heroin dependence; hospitalization; human; male; methodology; patient satisfaction; psychological aspect; statistics; withdrawal syndrome; Adult; Ambulatory Care; Buprenorphine; Buprenorphine; Detoxification; Dose regimes; Heroin withdrawal | |
| dc.title | Buprenorphine dosing regime in the management of out-patient heroin withdrawal | |
| dc.type | Journal article | |
| local.bibliographicCitation.lastpage | 45 | |
| local.bibliographicCitation.startpage | 39 | |
| local.contributor.affiliation | Lintzeris, Nicholas, College of Medicine, Biology and Environment, ANU | |
| local.contributor.authoruid | Lintzeris, Nicholas, u3910611 | |
| local.description.embargo | 2037-12-31 | |
| local.description.notes | Imported from ARIES | |
| local.description.refereed | Yes | |
| local.identifier.absfor | 111799 - Public Health and Health Services not elsewhere classified | |
| local.identifier.ariespublication | MigratedxPub14285 | |
| local.identifier.citationvolume | 21 | |
| local.identifier.doi | 10.1080/09595230220119309 | |
| local.identifier.scopusID | 2-s2.0-0036004062 | |
| local.type.status | Published Version |