Antitumor metallocenes: effect of DMSO on the stability of Cp 2 TiX 2 and implications for anticancer activity
Date
1998
Authors
Harding, Margaret
Mokdsi, George
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi Publishing Corporation
Abstract
The rate of hydrolysis of the aromatic rings of Cp2TiX2 [X = Cl 1, O2CCCl3 8 and O2CCH2NH3Cl 13], in aqueous solutions, 10% DMSO and 100% DMSO have been studied by 1H NMR spectroscopy. Rapid hydrolysis of both the carboxylate and cyclopentadienyl ligands
Description
Keywords
Keywords: antineoplastic metal complex; dimethyl sulfoxide; titanocene dichloride; antineoplastic activity; aqueous solution; conference paper; drug hydrolysis; drug stability; proton nuclear magnetic resonance
Citation
Collections
Source
Metal-Based Drugs
Type
Journal article
Book Title
Entity type
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2037-12-31