Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors

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dc.contributor.authorQuek, Gracia X J
dc.contributor.authorLin, Diana S-H
dc.contributor.authorHalliday, Jill
dc.contributor.authorAbsalom, Nathan
dc.contributor.authorAmbrus, Joseph
dc.contributor.authorThompson, Andrew J
dc.contributor.authorLochner, Martin
dc.contributor.authorLummis, Sarah
dc.contributor.authorMcLeod, Malcolm
dc.contributor.authorChebib, Mary
dc.date.accessioned2015-12-10T22:42:53Z
dc.date.issued2010
dc.date.updated2016-02-24T10:23:45Z
dc.description.abstractNeuronal nicotinic acetylcholine receptors (nAChR) are ligand gated ion channels that mediate fast synaptic transmission. Methyllycaconitine (MLA) is a selective and potent antagonist of the 7 nAChR, and its anthranilate ester side-chain is important for
dc.identifier.issn1948-7193
dc.identifier.urihttp://hdl.handle.net/1885/57985
dc.publisherAmerican Chemical Society
dc.sourceA C S Chemical Neuroscience
dc.subjectKeywords: acetylcholine; alcohol derivative; anthranilic acid derivative; methanethiosulfonate ethylammonium; methyllycaconitine; methyllycaconitine derivative; nicotinic receptor; thiomesylic acid methyl ester; unclassified drug; animal cell; article; binding site
dc.titleIdentifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors
dc.typeJournal article
local.bibliographicCitation.issue12
local.bibliographicCitation.lastpage809
local.bibliographicCitation.startpage796
local.contributor.affiliationQuek, Gracia X J, University of Sydney
local.contributor.affiliationLin, Diana S-H, University of Sydney
local.contributor.affiliationHalliday, Jill, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationAbsalom, Nathan, University of Sydney
local.contributor.affiliationAmbrus, Joseph, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationThompson, Andrew J, University of Cambridge
local.contributor.affiliationLochner, Martin, University of Bern
local.contributor.affiliationLummis, Sarah, University of Cambridge
local.contributor.affiliationMcLeod, Malcolm, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationChebib, Mary, University of Sydney
local.contributor.authoruidHalliday, Jill, u4547826
local.contributor.authoruidAmbrus, Joseph, u4562284
local.contributor.authoruidMcLeod, Malcolm, u4045340
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
local.identifier.ariespublicationu4005981xPUB423
local.identifier.citationvolume1
local.identifier.doi10.1021/cn100073x
local.identifier.scopusID2-s2.0-78650348790
local.identifier.thomsonID000285429300005
local.type.statusPublished Version

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