Eosinophils from Lineage-Ablated Delta dblGATA Bone Marrow Progenitors: The dblGATA Ehancer in the Promoter of GATA-1 Is Not Essential for Differentiation Ex Vivo

Dyer, Kimberley D; Czapiga, Meggan; Foster, Barbara; Foster, Paul S; Kang, Elizabeth M; Lappas, Courtney M.; Moser, Jennifer M; Naumann, Nora; Percopo, Caroline M.; Siegel, Steven J; Swartz, Jonathan M; Ting-De Ravin, SukSee; Rosenberg, Helene F

Eosinophils from Lineage-Ablated Delta dblGATA Bone Marrow Progenitors: The dblGATA Ehancer in the Promoter of GATA-1 Is Not Essential for Differentiation Ex Vivo

Date

2007

Authors

Dyer, Kimberley D

Czapiga, Meggan

Foster, Barbara

Foster, Paul S

Kang, Elizabeth M

Lappas, Courtney M.

Moser, Jennifer M

Naumann, Nora

Percopo, Caroline M.

Siegel, Steven J

Publisher

American Association of Immunologists

Abstract

A critical role for eosinophils in remodeling of allergic airways was observed in vivo upon disruption of the dblGATA enhancer that regulates expression of GATA-1, which resulted in an eosinophil-deficient phenotype in the ΔdblGATA mouse. We demonstrate