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The role of interchain heterodisulfide formation in activation of the human common β and mouse β IL-3 receptors

Date

Authors

Mirza, Shamaruh

Chen, Jinglong

Murphy, James M

Young, Ian

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

The cytokines, interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte-macrophage colony-stimulating factor (GM-CSF), exhibit overlapping activities in the regulation of hematopoietic cells. In humans, the common β (βc) receptor is shared by the thr

Keywords

Keywords: Binding epitopes; Cysteine residues; Cytokines; Granulocyte-macrophage colony-stimulating factors; Hematopoietic cell; High affinity binding; Interleukin-3; Interleukin-5; Isoforms; Ligand binding; Ligand-binding residues; N-terminal domains; N-terminals;

URI

http://hdl.handle.net/1885/37582

Collections

ANU Research Publications

Source

Journal of Biological Chemistry

Type

Journal article

DOI

10.1074/jbc.M109.097881

Restricted until

2037-12-31

Downloads

File

Description

01_Mirza_The_role_of_interchain_2010.pdf (2.09 MB)

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