Phyto-estrogen intake and plasma concentrations in South Asian and British women resident in England

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dc.contributor.authorBhakta, Dee
dc.contributor.authorHiggins, Craig D
dc.contributor.authorSevak, Leena
dc.contributor.authorMangtani, Punam
dc.contributor.authorAdlecreutz, Herman
dc.contributor.authorMcMichael, Anthony
dc.contributor.authordos Santos Silva, Isabel
dc.date.accessioned2015-12-07T22:23:38Z
dc.date.issued2006
dc.date.updated2015-12-07T09:20:49Z
dc.description.abstractPhyto-oestrogens, naturally occurring hormone-like chemicals in plant food, may play a protective role against hormone-related chronic diseases. South Asian migrants in the UK have a lower incidence of hormone-related cancer than their hosts but the extent to which this difference may be due to phytoestrogen intake is not known. The aim was to compare habitual phytoestrogen intake in first-generation South Asian migrant women and native British women. South Asian (n 221) and native British women (n 50) were recruited from general practitioner lists and were asked to provide monthly 24 h recalls for a period of 1 year. An enhanced phytoestrogen database was compiled using data from a literature search and unpublished data. A sub-sample of South Asian women (n 100) and the native British women (n 40) also provided blood samples every 3 months during the 1-year period. The median daily intakes (μg/d) of isoflavones (184.2 v. 333.9) and lignans (110.8 v. 148.8) were significantly lower in South Asians than in the native British (P < 0.001, P = 0.04 respectively). There were no significant differences in mean plasma isoflavone levels (nmol/l) but plasma enterolactone was significantly lower in the South Asians (13.9 (SD17.5) v. 28.5 (SD23.3), P<0.001). The main sources of phytoestrogens were bread and vegetables in both ethnic groups. Habitual phytoestrogen intake in South Asian and native British women was below 1 mg/d and was higher in the native British diet. The present study does not support the hypothesis that differences in phytoestrogen intake, or in circulating levels, could explain differences in hormone-related cancer risks between these two populations.
dc.identifier.issn0007-1145
dc.identifier.urihttp://hdl.handle.net/1885/20799
dc.publisherCambridge University Press
dc.sourceBritish Journal of Nutrition
dc.subjectKeywords: enterolactone; isoflavone derivative; lignan derivative; phytoestrogen; adult; article; Asian; blood sampling; bread; breast cancer; cancer prevention; cancer risk; controlled study; data base; documentation; eating habit; estrogen blood level; ethnic gro 24-h recall; Daidzein; Enterolactone; Genistein; Isoflavones; Lignans; Phytoestrogen; South Asian diet
dc.titlePhyto-estrogen intake and plasma concentrations in South Asian and British women resident in England
dc.typeJournal article
local.bibliographicCitation.issue6
local.bibliographicCitation.lastpage1158
local.bibliographicCitation.startpage1150
local.contributor.affiliationBhakta, Dee, University of London
local.contributor.affiliationHiggins, Craig D, University of London
local.contributor.affiliationSevak, Leena, University of London
local.contributor.affiliationMangtani, Punam, University of London
local.contributor.affiliationAdlecreutz, Herman, University of Helsinki
local.contributor.affiliationMcMichael, Anthony, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationdos Santos Silva, Isabel, University of London
local.contributor.authoremailu4036618@anu.edu.au
local.contributor.authoruidMcMichael, Anthony, u4036618
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationU4054856xPUB14
local.identifier.citationvolume95
local.identifier.doi10.1079/BJN20061777
local.identifier.scopusID2-s2.0-33745625328
local.identifier.uidSubmittedByU4054856
local.type.statusPublished Version

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