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Differential expression of the actin-binding proteins, α-actinin-2 and -3, in different species: implications for the evolution of functional redundancy

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Mills, Michelle
Yang, Nan
Weinberger, Ron
Vander Woude, Douglas
Beggs, Alan H
Easteal, Simon
North, Kathryn

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Oxford University Press

Abstract

The α-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of α-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin fil

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Human Molecular Genetics

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2037-12-31