Antibodies to Leptospira among blood donors in higher-risk areas of Australia: Possible implications for transfusion safety

dc.contributor.authorFaddy, Helen
dc.contributor.authorSeed, Clive
dc.contributor.authorLau, Colleen
dc.contributor.authorRacloz, Vanessa
dc.contributor.authorFlower, Robert
dc.contributor.authorSmythe, Lee D
dc.contributor.authorBurns, Mary-Anne
dc.contributor.authorDohnt, Michael
dc.contributor.authorCraig, Scott
dc.contributor.authorHarley, Robert
dc.contributor.authorWeinstein, Philip
dc.date.accessioned2018-11-29T22:55:47Z
dc.date.available2018-11-29T22:55:47Z
dc.date.issued2015
dc.date.updated2018-11-29T08:08:23Z
dc.description.abstractBACKGROUND: Leptospirosis is one of the most common bacterial zoonoses worldwide, and clinical manifestations range from asymptomatic infection to acute febrile illness, multi-organ failure and death. Asymptomatic, acute bacteraemia in a blood donor provides a potential for transfusion-transmission, although only a single such case from India has been recorded. Human leptospirosis is uncommon in developed countries; however, the state of Queensland in Australia has one of the highest rates among developed countries, especially after increased rainfall. This study examined the prevalence of antibodies to Leptospira spp. in blood donors residing in higher-risk areas of Australia, to evaluate the appropriateness of current blood safety guidelines. MATERIALS AND METHODS: Plasma samples collected from blood donors residing in higher-risk areas of Australia during 2009 and 2011 were included in the study. All samples were tested for the presence of antibodies to 22 leptospiral serovars using the microscopic agglutination test. RESULT: No sample had antibody titres suggestive of a current or recent infection, however, seven samples (1.44%, 95% CI: 0.38-2.50%) had titres suggestive of a past infection. DISCUSSION: This study provides data that may support the appropriateness of current relevant donor selection policies in Australia. Given that the risk profile for leptospirosis is expanding and that the infection is likely to become more prevalent with climate change, this disease may become more of a concern for transfusion safety in the future
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1723-2007
dc.identifier.urihttp://hdl.handle.net/1885/153289
dc.publisherSIMTI Servizi
dc.sourceBlood Transfusion
dc.subjectKeywords: bacterium antibody; adult; aged; agglutination test; antibody titer; Article; Australia; blood donor; blood safety; female; human; Leptospira; leptospirosis; major clinical study; male; practice guideline; seroprevalence; serotype Climate; Emerging pathogen; Rainfall
dc.titleAntibodies to Leptospira among blood donors in higher-risk areas of Australia: Possible implications for transfusion safety
dc.typeJournal article
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue1
local.bibliographicCitation.lastpage36
local.bibliographicCitation.startpage32
local.contributor.affiliationFaddy, Helen, Australian Red Cross Blood Service
local.contributor.affiliationSeed, Clive, Australian Red Cross Blood Service
local.contributor.affiliationLau, Colleen, College of Health and Medicine, ANU
local.contributor.affiliationRacloz, Vanessa, University of Queensland
local.contributor.affiliationFlower, Robert, Australian Red Cross Blood Service
local.contributor.affiliationSmythe, Lee D, Queensland Health Forensic and Scientific Services
local.contributor.affiliationBurns, Mary-Anne, Queensland Health Forensic and Scientific Services
local.contributor.affiliationDohnt, Michael, Queensland Health Forensic and Scientific Services
local.contributor.affiliationCraig, Scott, Queensland Health Forensic and Scientific Services
local.contributor.affiliationHarley, Robert, Australian Red Cross Blood Service
local.contributor.affiliationWeinstein, Philip, University of South Australia
local.contributor.authoremailu5651486@anu.edu.au
local.contributor.authoruidLau, Colleen, u5651486
local.description.notesImported from ARIES
local.identifier.absfor111700 - PUBLIC HEALTH AND HEALTH SERVICES
local.identifier.ariespublicationU3488905xPUB9049
local.identifier.citationvolume13
local.identifier.doi10.2450/2014.0012-14
local.identifier.scopusID2-s2.0-84922311155
local.identifier.thomsonID000351423200005
local.identifier.uidSubmittedByU3488905
local.type.statusPublished Version

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