Molecular and cellular mechanisms in the viral exacerbation of asthma

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dc.contributor.authorTauro, Sharyn
dc.contributor.authorSu, Yung-Chang
dc.contributor.authorThomas, Sandra
dc.contributor.authorSchwarze, Jurgen
dc.contributor.authorMatthaei, Klaus
dc.contributor.authorTownsend, Dijana
dc.contributor.authorSimson, Ljubov
dc.contributor.authorTripp, Ralph A
dc.contributor.authorMahalingam, Suresh (Surendran)
dc.date.accessioned2015-12-08T22:36:10Z
dc.date.issued2008
dc.date.updated2015-12-08T09:47:52Z
dc.description.abstractThe aetiology of asthma associated with viral infection is complex. The dynamics that contribute to disease pathogenesis are multifactorial and involve overlapping molecular and cellular mechanisms, particularly the immune response to respiratory virus infection or allergen sensitization. This review summarizes the evidence associated with factors that may contribute to the development or exacerbation of asthma including age, host factors, genetic polymorphisms, altered immune responses, and aspects of viral antigen expression. This review also provides an important perspective of key events linked to the development of asthmatic disease and related pulmonary inflammation from human and animal studies, and discusses their relationship as targets for disease intervention strategies.
dc.identifier.issn1286-4579
dc.identifier.urihttp://hdl.handle.net/1885/35138
dc.publisherElsevier
dc.sourceMicrobes and Infection
dc.subjectKeywords: acetylcholine; allergen; antivirus agent; chemokine; cytokine; epitope; histamine; immunoglobulin E antibody; interleukin 10; interleukin 13; interleukin 5; neutralizing antibody; peptidoleukotriene; prostaglandin; virus antigen; virus vaccine; acetylchol Asthma; Cellular mechanism; Molecular mechanism; Pulmonary inflammation; Viral aetiology
dc.titleMolecular and cellular mechanisms in the viral exacerbation of asthma
dc.typeJournal article
local.bibliographicCitation.lastpage1023
local.bibliographicCitation.startpage1014
local.contributor.affiliationTauro, Sharyn, University of Canberra
local.contributor.affiliationSu, Yung-Chang, University of Canberra
local.contributor.affiliationThomas, Sandra, University of Canberra
local.contributor.affiliationSchwarze, Jurgen, University of Edinburgh
local.contributor.affiliationMatthaei, Klaus, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTownsend, Dijana, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSimson, Ljubov, University of Canberra
local.contributor.affiliationTripp, Ralph A, University of Georgia
local.contributor.affiliationMahalingam, Suresh (Surendran), University of Canberra
local.contributor.authoremailu8200697@anu.edu.au
local.contributor.authoruidMatthaei, Klaus, u8200697
local.contributor.authoruidTownsend, Dijana, u4380287
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110701 - Allergy
local.identifier.ariespublicationu4020362xPUB121
local.identifier.citationvolume10
local.identifier.doi10.1016/j.micinf.2008.07.037
local.identifier.scopusID2-s2.0-53549095955
local.identifier.thomsonID000260888300014
local.identifier.uidSubmittedByu4020362
local.type.statusPublished Version

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