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The efficacy of cidofovir treatment of mice infected with ectromelia (mousepox) virus encoding interleukin-4

Date

Authors

Robbins, S

Jackson, Ronald

Fenner, Frank

Beaton, S

Medveczky, C

Ramshaw, Ian

Ramsay, Alistair

Publisher

Elsevier

Abstract

Improved vaccines and therapies for virulent poxvirus infection are required, particularly in the light of recent threats of bioterrorism. Cidofovir (HPMPC) is an acyclic nucleoside analog with proven efficacy against poxviruses. Here, we evaluated HPMPC

Keywords

Keywords: cidofovir; interleukin 4; animal model; animal tissue; cellular immunity; controlled study; drug effect; drug efficacy; drug megadose; Ectromelia virus; lethality; mortality; mouse; nonhuman; Poxvirus infection; priority journal; review; single drug dose; Cidofovir; Immune suppression; Interleukin-4; Mousepox infection

URI

http://hdl.handle.net/1885/81914

Collections

ANU Research Publications

Source

Antiviral Research

Type

Journal article

DOI

10.1016/j.antiviral.2004.12.003

Restricted until

2037-12-31

Downloads

File

Description

01_Robbins_The_efficacy_of_cidofovir_2005.pdf (143.41 KB)