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Multiple actions of {varphi}-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

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Date

2013

Authors

Smith, Jennifer J.
Vetter, Irina
Lewis, Richard J.
Peigneur, Steve
Tytgat, Jan
Lam, Alex
Gallant, Esther
Beard, Nicole
Alewood, Paul F
Dulhunty, Angela

Journal Title

Journal ISSN

Volume Title

Publisher

National Academy of Sciences (USA)

Abstract

We recently reported the isolation of a scorpion toxin named U1-liotoxin-Lw1a (U1-LITX-Lw1a) that adopts an unusual 3D fold termed the disulfide-directed hairpin (DDH) motif, which is the proposed evolutionary structural precursor of the three-disulfide-c

Description

Keywords

Keywords: liotoxin; ryanodine receptor; scorpion disulfide directed hairpin toxin; scorpion inhibitor cystine knot toxin; scorpion venom; toxin; unclassified drug; calcium channel L type; disulfide; tritium; article; binding site; calcium transport; malignant hyper

Citation

URI

http://hdl.handle.net/1885/55285

Collections

ANU Research Publications

Source

PNAS - Proceedings of the National Academy of Sciences of the United States of America

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1073/pnas.1214062110

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01_Smith_Multiple_actions_of_2013.pdf (1.12 MB)

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