Chemokines in Eosinophil-associated Gastrointestinal Disorders
Date
2004
Authors
Hogan, Simon
Rothenberg, Marc
Forbes, Elizabeth
Prescott, Vanessa
Matthaei, Klaus
Foster, Paul S
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Volume Title
Publisher
Current Science Inc
Abstract
Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.
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Keywords
Keywords: alpha chemokine; beta chemokine; CD4 antigen; chemokine; chemokine receptor CCR1; chemokine receptor CCR2; chemokine receptor CCR3; chemokine receptor CCR4; chemokine receptor CCR5; chemokine receptor CCR6; chemokine receptor CCR7; chemokine receptor CCR8
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Source
Current allergy and Asthma Reports
Type
Journal article
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Restricted until
2037-12-31
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