A convenient synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid
Date
2003
Authors
Barker, David
Brimble, Margaret A
McLeod, Malcolm
Journal Title
Journal ISSN
Volume Title
Publisher
Georg Thieme Verlag
Abstract
A new procedure for the synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1yl)benzoic acid (3) is reported via hydrogenation of 2-(3-methyl-2,5-dihydropyrrol-1-yl)benzoic acid (9) that in turn is available from fusion of anthranilic acid with citraconic anhydride. This method provides cleaner material in higher overall yield than that obtained using previously reported methods.
Description
Keywords
Keywords: Hydrides; Hydrogenation; Synthesis (chemical); Benzoic acids; Organic acids; 2 (3 methyl 2,5 dihydropyrrol 1 yl)benzoic acid; 2 (3 methyl 2,5 dioxopyrrolidin 1 yl)benzoic acid; anthranilic acid; benzoic acid derivative; citraconic anhydride; unclassified Acids; Alkaloids; Amines; Anhydrides; Hydrogenation
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Source
Synthesis
Type
Journal article