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Does gene dosage really matter?

Date

Authors

Graves, Jennifer

Disteche, Christine M

Publisher

BioMed Central

Abstract

Mechanisms to compensate for dosage differences of genes on sex chromosomes are widespread in animals and have been thought to be critical for viability. However, in birds, compensation is inefficient, implying that for many genes dosage compensation is not critical, and for some genes, dosage differences have even been selected for.

Keywords

Keywords: cell viability; gene; gene dosage; gene expression regulation; genetic difference; human; nonhuman; priority journal; regulatory mechanism; sex chromosome; short survey; animal; bird; Drosophila; female; genetics; male; mammal; mouse; note; Animalia; Aves

Citation

Journal of Biology 6.1 (2007)

URI

http://hdl.handle.net/10440/106
http://digitalcollections.anu.edu.au/handle/10440/106

Collections

ANU Research Publications

Source

Journal of Biology

Type

Journal article

DOI

10.1186/jbiol55

Downloads

File

Description

Graves_Does.pdf (99.77 KB)

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