Comparison of international normalized ratio audit parameters in patients enrolled in GARFIELD-AF and treated with vitamin K antagonists

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dc.contributor.authorFitzmaurice, David
dc.contributor.authorAccetta, G
dc.contributor.authorHaas, Sylvia
dc.contributor.authorKayani, Gloria
dc.contributor.authorLuciardi, H
dc.contributor.authorMisselwitz, F
dc.contributor.authorPieper, K
dc.contributor.authorten Cate, Hugo
dc.contributor.authorTurpie, Alexander
dc.contributor.authorKakkar, Ajay
dc.contributor.authorAbhayaratna, Walter
dc.date.accessioned2022-06-08T00:19:18Z
dc.date.issued2016
dc.date.updated2021-01-17T07:19:19Z
dc.description.abstractVitamin K antagonist (VKA) therapy for stroke prevention in atrial fibrillation (AF) requires monitoring of the international normalized ratio (INR). We evaluated the agreement between two INR audit parameters, frequency in range (FIR) and proportion of time in the therapeutic range (TTR), using data from a global population of patients with newly diagnosed nonvalvular AF, the Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF). Among 17 168 patients with 1-year follow-up data available at the time of the analysis, 8445 received VKA therapy ( antiplatelet therapy) at enrolment, and of these patients, 5066 with ≥3 INR readings and for whom both FIR and TTR could be calculated were included in the analysis. In total, 70 905 INRs were analysed. At the patient level, TTR showed higher values than FIR (mean, 560% vs 498%; median, 597% vs 500%). Although patient-level FIR and TTR values were highly correlated (Pearson correlation coefficient [95% confidence interval; CI], 0860 [0852–0867]), estimates from individuals showed widespread disagreement and variability (Lin’s concordance coefficient [95% CI], 0829 [0821–0837]). The difference between FIR and TTR explained 174% of the total variability of measurements. These results suggest that FIR and TTR are not equivalent and cannot be used interchangeably.en_AU
dc.description.sponsorshipThe GARFIELD-AF registry is sponsored by the Thrombosis Research Institute, London, UK, and is supported by an unrestricted research grant from Bayer Pharma AG, Berlin, Germany.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0007-1048en_AU
dc.identifier.urihttp://hdl.handle.net/1885/267219
dc.language.isoen_AUen_AU
dc.publisherBlackwell Publishing Ltden_AU
dc.rights© 2016 John Wiley & Sons Ltden_AU
dc.sourceBritish Journal of Haematologyen_AU
dc.subjectatrial fibrillationen_AU
dc.subjectfrequency in rangeen_AU
dc.subjectinternational normalized ratioen_AU
dc.subjecttime in therapeutic rangeen_AU
dc.subjectvitamin K antagonistsen_AU
dc.titleComparison of international normalized ratio audit parameters in patients enrolled in GARFIELD-AF and treated with vitamin K antagonistsen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue4en_AU
local.bibliographicCitation.lastpage623en_AU
local.bibliographicCitation.startpage610en_AU
local.contributor.affiliationFitzmaurice, David, University of Birminghamen_AU
local.contributor.affiliationAccetta, G, Thrombosis Research Instituteen_AU
local.contributor.affiliationHaas, Sylvia, Technical University of Munichen_AU
local.contributor.affiliationKayani, Gloria, Thrombosis Research Instituteen_AU
local.contributor.affiliationLuciardi, H, University of Tucumánen_AU
local.contributor.affiliationMisselwitz, F, Bayer HealthCare Pharmaceuticalsen_AU
local.contributor.affiliationPieper, K, Duke Clinical Research Instituteen_AU
local.contributor.affiliationten Cate, Hugo, Maastricht University Medical Center,en_AU
local.contributor.affiliationTurpie, Alexander, McMaster Universityen_AU
local.contributor.affiliationKakkar, Ajay, Thrombosis Research Instituteen_AU
local.contributor.affiliationAbhayaratna, Walter, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu3379649@anu.edu.auen_AU
local.contributor.authoruidAbhayaratna, Walter, u3379649en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor110201 - Cardiology (incl. Cardiovascular Diseases)en_AU
local.identifier.absseo920103 - Cardiovascular System and Diseasesen_AU
local.identifier.ariespublicationu5369653xPUB200en_AU
local.identifier.citationvolume174en_AU
local.identifier.doi10.1111/bjh.14084en_AU
local.identifier.uidSubmittedByu5369653en_AU
local.publisher.urlhttps://www.wiley.com/en-gben_AU
local.type.statusPublished Versionen_AU

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