Integrated research into the nanoparticle-protein corona: a new focus for safe, sustainable and equitable development of nanomedicines

Date

2008

Authors

White, John
Matthaei, Klaus
Faunce, Thomas

Journal Title

Journal ISSN

Volume Title

Publisher

Future Science Group

Abstract

Much contemporary nanotoxicology, nanotherapeutic and nanoregulatory research has been characterized by a focus on investigating how delivery of engineered nanoparticles (ENPs) to cells is dictated primarily by components of the ENP surface. An alternative model, some implications of which are discussed here, begins with fundamental physicochemical research into the interaction of a dynamic nanoparticle-protein corona (NPC) with biological systems. The proposed new model also requires, however, that any such fresh NPC physicochemical research approach should involve integration and targeted collaboration from the earliest stages with nanotoxicology, nanotherapeutics and nanoregulatory expertise. The justification for this integrated approach, we argue, relates not just to efficiency and promotion of innovation but to an acknowledgement that public-funded basic physicochemical research in particular should now be accepted to incorporate strong higher order public-goods elements from its inception, not merely after product development at the technology-transfer stage. Issues, such as university-research cooperation, commercialization and intellectual property protection, safety and cost-effectiveness regulatory assessment, as well as technology transfer should not be viewed as second tier considerations, even in a 'blue sky' NPC basic research agenda.

Description

Keywords

Keywords: asbestos; carbon nanotube; fullerene derivative; gamma interferon; interleukin 4; macrogol; mevinolin; nanocomposite; nanoparticle; polystyrene; povidone; quantum dot; superparamagnetic iron oxide; article; asbestosis; embryonic stem cell; human; immunoge Cost-effectiveness; Nanomedicine; Nanoparticle-protein corona; Nanotoxicology; Safety regulation; Technology transfer

Citation

Source

Nanomedicine

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.2217/17435889.3.6.859

Restricted until

2037-12-31