Surgical outcomes of borderline breast lesions detected by needle biopsy in a breast screening program

Simple item page
dc.contributor.authorFlegg, Karen M
dc.contributor.authorFlaherty, Jeffrey J
dc.contributor.authorBicknell, Anne M
dc.contributor.authorJain, Sanjiv
dc.date.accessioned2015-10-02T04:56:04Z
dc.date.available2015-10-02T04:56:04Z
dc.date.issued2010-09-08
dc.date.updated2015-12-10T09:41:48Z
dc.description.abstractBACKGROUND The Australian Capital Territory and South East New South Wales branch of BreastScreen Australia (BreastScreen ACT&SENSW) performs over 20,000 screening mammograms annually. This study describes the outcome of surgical biopsies of the breast performed as a result of a borderline lesion being identified after screening mammography and subsequent workup.A secondary aim was to identify any parameters, such as a family history of breast cancer, or radiological findings that may indicate which borderline lesions are likely to be upgraded to malignancy after surgery. METHODS From a period of just over eight years, all patients of BreastScreen ACT&SENSW who were diagnosed with a borderline breast lesion were identified. These women had undergone needle biopsy in Breastscreen ACT&SENSW and either atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), atypical lobular hyperplasia (ALH), radial scar/complex sclerosing lesion, papillary lesion, mucocoele-like lesion (MLL) or lobular carcinoma in situ (LCIS) was found. Final outcomes for each type of borderline lesion after referral for surgical biopsy were recorded and analysed. Results of the surgical biopsy were compared to the type of needle biopsy and its result, radiological findings and family history status. RESULTS Of the 94 surgical biopsies performed due to the presence of a borderline breast lesion, 20% showed benign pathology, 55% remained as borderline lesions, 17% showed non-invasive malignancy and 7% showed invasive malignancy. VALCS biopsy was the most common needle biopsy method used to identify the lesions in this study (76%). Malignant outcomes resulted from 24% of the surgical biopsies, with the most common malignant lesion being non-comedo ductal carcinoma in situ (DCIS). The most common borderline lesion for which women underwent surgical biopsy was ADH (38%). Of these women, 22% were confirmed as ADH on surgical biopsy and 47% with a malignancy. CONCLUSIONS Further research is required to determine whether characteristics of the mammographic lesion (particularly calcification patterns), the area targeted for biopsy and number of core samples retrieved, can indicate a closer correlation with eventual pathology. This study identified no findings in the diagnostic assessment that could exclude women with borderline lesions from surgical biopsy.
dc.identifier.issn1477-7819en_AU
dc.identifier.urihttp://hdl.handle.net/1885/15762
dc.publisherBioMed Central
dc.rights© 2010 Flegg et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.sourceWorld Journal of Surgical Oncology
dc.subjectaged
dc.subjectbiopsy, needle
dc.subjectbreast neoplasms
dc.subjectdiagnosis, differential
dc.subjectfemale
dc.subjectfollow-up studies
dc.subjecthumans
dc.subjectmass screening
dc.subjectmastectomy
dc.subjectmiddle aged
dc.subjectneoplasm staging
dc.subjectnew south wales
dc.subjecttreatment outcome
dc.titleSurgical outcomes of borderline breast lesions detected by needle biopsy in a breast screening program
dc.typeJournal article
local.bibliographicCitation.issue1en_AU
local.bibliographicCitation.startpage78en_AU
local.contributor.affiliationFlegg, Karen, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National Universityen_AU
local.contributor.affiliationFlaherty, Jeffrey, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National Universityen_AU
local.contributor.affiliationBicknell, Anne, ACT Health, Australiaen_AU
local.contributor.affiliationJain, Sanjiv, City Hospital Birmingham, United Kingdomen_AU
local.contributor.authoremailkaren.flegg@anu.edu.auen_AU
local.contributor.authoruidu5036429en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor111202en_AU
local.identifier.ariespublicationf2965xPUB963en_AU
local.identifier.citationvolume8en_AU
local.identifier.doi10.1186/1477-7819-8-78en_AU
local.identifier.essn1477-7819en_AU
local.identifier.scopusID2-s2.0-77956473047
local.identifier.thomsonID000282612000001
local.identifier.uidSubmittedByu3488905en_AU
local.publisher.urlhttp://www.biomedcentral.com/en_AU
local.type.statusPublished Versionen_AU

Downloads

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
01_Flegg_Surgical_outcomes_of_2010.pdf
Size:
234.32 KB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
884 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2024 LYRASIS