Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance
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Authors
Chatzigeorgiou, Antonios
Seijkens, Tom
Zarzycka, Barbara
Engel, David
Poggi, Marjorie
van den Berg, Susan
van den Berg, Sjoerd
Soehnlein, Oliver
Winkels, Holger
Beckers, Linda
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National Academy of Sciences (USA)
Abstract
The immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced obesity (DIO). Although
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PNAS - Proceedings of the National Academy of Sciences of the United States of America
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Open Access