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Restricted Semliki Forest virus replication inperforin and Fas-ligand double-deficient mice

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dc.contributor.authorAlsharifi, Mohammed
dc.contributor.authorLobigs, Mario
dc.contributor.authorBettadapura, Jayaram
dc.contributor.authorKoskinen, Aulikki
dc.contributor.authorMullbacher, Arno
dc.date.accessioned2015-12-08T22:16:04Z
dc.date.issued2008
dc.date.updated2015-12-08T07:57:35Z
dc.description.abstractPreviously, we have shown that mice defective in granule exocytosis and/ or Fas.L/Fas-mediated cytolytic pathways are significantly more resistant to alphavirus, Semliki Forest virus (SFV), infection compared with wild-type mice. Here, we evaluated SFV replication in different tissues of mice defective in both cytolytic pathways (perf-/-xg/d) relative to that in wild-type counterparts and found that viral replication in perf-/-xg/d mice is remarkably restricted. Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic effector molecules in antiviral immunity needs to be re-evaluated.
dc.identifier.issn0022-1317
dc.identifier.urihttp://hdl.handle.net/1885/30513
dc.publisherSociety for General Microbiology
dc.sourceJournal of General Virology
dc.subjectKeywords: Fas ligand; perforin; animal experiment; animal model; animal tissue; article; brain tissue; controlled study; cytolysis; mouse; muscle; nonhuman; priority journal; Semliki Forest alphavirus; signal transduction; spleen; tissue specificity; Togavirus infe
dc.titleRestricted Semliki Forest virus replication inperforin and Fas-ligand double-deficient mice
dc.typeJournal article
local.bibliographicCitation.issue8
local.bibliographicCitation.lastpage1944
local.bibliographicCitation.startpage1942
local.contributor.affiliationAlsharifi, Mohammed, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLobigs, Mario, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBettadapura, Jayaram, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKoskinen, Aulikki, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMullbacher, Arno, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidAlsharifi, Mohammed, a265709
local.contributor.authoruidLobigs, Mario, u8506091
local.contributor.authoruidBettadapura, Jayaram, u4042976
local.contributor.authoruidKoskinen, Aulikki, u9108883
local.contributor.authoruidMullbacher, Arno, u8102295
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110804 - Medical Virology
local.identifier.ariespublicationu6800332xPUB74
local.identifier.citationvolume89
local.identifier.doi10.1099/vir.0.83626-0
local.identifier.scopusID2-s2.0-50549102881
local.identifier.thomsonID000258301800017
local.type.statusPublished Version

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