Characterization of the Stability and Bio-functionality of Tethered Proteins on Bioengineered Scaffolds: Implications for stem cell biology and tissue repair

Abstract

Background: Tethering proteins onto bioengineered scaffolds enables longterm delivery, however protein stability, release kinetics, and functionality over time remains unknown. Results: Tethered proteins remain stable and functional for several months, capable of activating intracellular signaling pathways and influencing cell fate. Conclusion: Tethered proteins are stable and functional long-term. Significance: Such knowledge may have implications for promoting tissue repair. Show more