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Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory

Date

Authors

Martin, Stephen

Goodnow, Christopher

Publisher

Nature Publishing Group

Abstract

The basis of immune memory leading to heightened secondary antibody responses is a longstanding unanswered issue. Here we show that a single irreversible molecular change in the B cell antigen receptor, which is brought about by immunoglobulin M (IgM) to

Keywords

Keywords: B lymphocyte receptor; immunoglobulin G; immunoglobulin M; animal cell; animal experiment; animal tissue; antibody response; antigen specificity; article; B lymphocyte; cell count; controlled study; immunological memory; in vivo study; lymphocyte prolifer

URI

http://hdl.handle.net/1885/94594

Collections

ANU Research Publications

Source

Nature Immunology

Type

Journal article

DOI

Restricted until

2037-12-31

Downloads

File

Description

01_Martin_Burst-enhancing_role_of_the_2002.pdf (470.33 KB)