Obesity-induced metabolic disturbance drives oxidative stress and complement activation in the retinal environment

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dc.contributor.authorNatoli, Riccardo
dc.contributor.authorFernando, Nilisha
dc.contributor.authorDahlenburg, Tess
dc.contributor.authorJiao, Haihan
dc.contributor.authorAggio-Bruce, Riemke
dc.contributor.authorBarnett, Nigel L.
dc.contributor.authorChao De La Barca, Juan
dc.contributor.authorTcherkez, Guillaume
dc.contributor.authorReynier, Pascal
dc.contributor.authorChu-Tan, Joshua
dc.contributor.authorValter, Krisztina
dc.contributor.authorProvis, Jan
dc.contributor.authorRutar, Matthew
dc.date.accessioned2019-07-12T01:41:33Z
dc.date.available2019-07-12T01:41:33Z
dc.date.issued2018
dc.date.updated2019-03-31T07:19:05Z
dc.description.abstractPurpose Systemic increases in reactive oxygen species, and their association with inflammation, have been proposed as an underlying mechanism linking obesity and age-related macular degeneration (AMD). Studies have found increased levels of oxidative stress biomarkers and inflammatory cytokines in obese individuals; however, the correlation between obesity and retinal inflammation has yet to be assessed. We used the leptin-deficient (ob/ob) mouse to further our understanding of the contribution of obesity to retinal oxidative stress and inflammation.en_AU
dc.description.sponsorshipThis study was supported by an Australian Government Research Training Program (RTP) Scholarship.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1090-0535en_AU
dc.identifier.urihttp://hdl.handle.net/1885/164546
dc.language.isoen_AUen_AU
dc.provenancehttp://www.molvis.org/molvis/instructions.html...Creative Commons Attribution-NonCommercial-NoDerivatives License 3.0, or CC BY-NC-ND 3.0 (see http://creativecommons.org/licenses/by-nc-nd/3.0/ for license terms). - from the publisher site (as at 12/07/2019).en_AU
dc.publisherMolecular Visionen_AU
dc.rights© 2018 Molecular Vision © The Author(s) 2018en_AU
dc.rights.licenseCreative Commons Attribution-NonCommercial-NoDerivatives License 3.0en_AU
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_AU
dc.sourceMolecular Visionen_AU
dc.titleObesity-induced metabolic disturbance drives oxidative stress and complement activation in the retinal environmenten_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.lastpage217en_AU
local.bibliographicCitation.startpage201en_AU
local.contributor.affiliationNatoli, Riccardo, College of Health and Medicine, ANUen_AU
local.contributor.affiliationFernando, Nilisha, College of Health and Medicine, ANUen_AU
local.contributor.affiliationDahlenburg, Tess, College of Health and Medicine, ANUen_AU
local.contributor.affiliationJiao, Haihan, College of Health and Medicine, ANUen_AU
local.contributor.affiliationAggio-Bruce, Riemke, College of Health and Medicine, ANUen_AU
local.contributor.affiliationBarnett, Nigel L, University of Queenslanden_AU
local.contributor.affiliationChao De La Barca, Juan, College of Health and Medicine, ANUen_AU
local.contributor.affiliationTcherkez, Guillaume, College of Science, ANUen_AU
local.contributor.affiliationReynier, Pascal, Universite d'Angersen_AU
local.contributor.affiliationChu-Tan, Joshua, College of Health and Medicine, ANUen_AU
local.contributor.affiliationValter, Krisztina, College of Health and Medicine, ANUen_AU
local.contributor.affiliationProvis, Jan, College of Health and Medicine, ANUen_AU
local.contributor.affiliationRutar, Matthew, College of Health and Medicine, ANUen_AU
local.contributor.authoruidNatoli, Riccardo, u4100537en_AU
local.contributor.authoruidFernando, Nilisha, u4672578en_AU
local.contributor.authoruidDahlenburg, Tess, u5183544en_AU
local.contributor.authoruidJiao, Haihan, u4861098en_AU
local.contributor.authoruidAggio-Bruce, Riemke, u5333366en_AU
local.contributor.authoruidChao De La Barca, Juan, u1004391en_AU
local.contributor.authoruidTcherkez, Guillaume, u4641357en_AU
local.contributor.authoruidChu-Tan, Joshua, u5025022en_AU
local.contributor.authoruidValter, Krisztina, u4055998en_AU
local.contributor.authoruidProvis, Jan, u4118802en_AU
local.contributor.authoruidRutar, Matthew, u4125807en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor111301 - Ophthalmologyen_AU
local.identifier.absseo920107 - Hearing, Vision, Speech and Their Disordersen_AU
local.identifier.ariespublicationa383154xPUB9810en_AU
local.identifier.citationvolume24en_AU
local.identifier.scopusID2-s2.0-85046091016
local.publisher.urlhttp://www.molvis.org/molvis/en_AU
local.type.statusPublished Versionen_AU

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