A cross-metathesis approach to novel pantothenamide derivatives
Loading...
Date
Authors
Guan, Jinming
Hachey, Matthew
Puri, Lekha
Howieson, Vanessa
Saliba, Kevin
Auclair, Karine
Journal Title
Journal ISSN
Volume Title
Publisher
Beilstein-Institut
Abstract
Pantothenamides are known for their in vitro antimicrobial activity. Our group has previously reported a new stereoselective route to access derivatives modified at the geminal dimethyl moiety. This route however fails in the addition of large substituents. Here we report a new synthetic route that exploits the known allyl derivative, allowing for the installation of larger groups via crossmetathesis. The method was applied in the synthesis of a new pantothenamide with improved stability in human blood.
Description
Keywords
Citation
Collections
Source
Beilstein Journal of Organic Chemistry
Type
Book Title
Entity type
Access Statement
Open Access
License Rights
Restricted until
Downloads
File
Description