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Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?

Date

Authors

Clark, Ian A

Atwood, Craig S.

Publisher

IOS Press

Abstract

This commentary addresses a novel mechanism by which aging-related changes in reproductive hormones could mediate their action in the brain. It presents the evidence that dyotic endocrine signals modulate the expression of tumor necrosis factor (TNF) and

Keywords

Keywords: amyloid beta protein; amyloid precursor protein; estradiol; etanercept; follitropin; gonadorelin; gonadotropin; interleukin 1beta; interleukin 6; leuprorelin; luteinizing hormone; monocyte chemotactic protein 1; oxytocin; progesterone; signal peptide; tes Alzheimer's disease; anxiety; cell cycle; dyotic signaling; endocrine dyscrasia; etanercept; inflammation; oxytocin; sex hormones; tumor necrosis factor (TNF)

URI

http://hdl.handle.net/1885/21118

Collections

ANU Research Publications

Source

Journal of Alzheimer's Disease

Type

Journal article

DOI

10.3233/JAD-2011-110887

Restricted until

2037-12-31

Downloads

File

Description

01_Clark_Is_TNF_a_link_between_2011.pdf (86.18 KB)