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Identification and characterization of a Ross River virus variant that grows persistently in macrophages, shows altered disease kinetics in a mouse model, and exhibits resistance to type I interferon

Date

2011

Authors

Lidbury, Brett
Rulli, Nestor E.
Musso, Cristina M
Cossetto, Susan B
Zaid, Ali
Suhrbier, Andreas
Rothenfluh, Harald
Rolph, Michael S
Mahalingam, Suresh (Surendran)

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Microbiology

Abstract

Alphaviruses, such as chikungunya virus, o'nyong-nyong virus, and Ross River virus (RRV), cause outbreaks of human rheumatic disease worldwide. RRV is a positive-sense single-stranded RNA virus endemic to Australia and Papua New Guinea. In this study, we

Description

Keywords

Keywords: alpha interferon; beta interferon; interferon; nonstructural protein; nonstructural protein 1; nucleotide; unclassified drug; virus protein; Alphavirus infection; animal cell; animal experiment; animal model; article; cell line; cell strain RAW264.7; cell

Citation

URI

http://hdl.handle.net/1885/17952

Collections

ANU Research Publications

Source

Journal of Virology

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1128/JVI.01189-10

Restricted until

Downloads

File
Description
01_Lidbury_Identification_and_2011.pdf (1.51 MB)

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