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Species Variability in Cardiovascular Research: The Example of Adrenocorticotrophin-Induced Hypertension

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Date

2006

Authors

Whitworth, Judith
Zhang, Yi
Mangos, George
Kelly, John J

Journal Title

Journal ISSN

Volume Title

Publisher

Blackwell Science Asia

Abstract

1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.

Description

Keywords

Keywords: arginine; atenolol; beta adrenergic receptor blocking agent; corticotropin; minoxidil; nisoldipine; nitric oxide; ramipril; tetracosactide; tetracosactide zinc phosphate; blood pressure; cardiovascular effect; conference paper; human; hypertension; kidney Blood pressure; Dog; Humans; Mouse; Rat; Sheep; Steroids

Citation

URI

http://hdl.handle.net/1885/18537

Collections

ANU Research Publications

Source

Clinical and Experimental Pharmacology and Physiology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1111/j.1440-1681.2006.04460.x

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