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The Role of Fas Ligand in Beta Cell Destruction in Autoimmune Diabetes of NOD Mice

Date

Authors

Petrovsky, Nikolai

Silva, D

Socha, L

Slattery, Robyn

Charlton, Brett

Publisher

New York Academy of Sciences

Abstract

Fas ligand (FasL), a type 2 membrane protein belonging to the TNF family, plays an important role in the induction of cell death. Ligation of Fas receptors by FasL results in apoptosis of the Fas-expressing cell. Autoimmune diabetes results from β cell d

Keywords

Keywords: cytokine; FAS ligand; animal experiment; animal model; apoptosis; autoimmune disease; cell destruction; conference paper; controlled study; cytokine release; flow cytometry; immunohistochemistry; insulin dependent diabetes mellitus; mouse; mouse strain; n Apoptosis; Autoimmunity; Diabetes; Fas; Fas ligand; NOD mice

URI

http://hdl.handle.net/1885/67743

Collections

ANU Research Publications

Source

Annals of the New York Academy of Sciences

Type

Journal article

Restricted until

2037-12-31

Downloads

File

Description

01_Petrovsky_The_Role_of_Fas_Ligand_in_Beta_2002.pdf (725.63 KB)

02_Petrovsky_The_Role_of_Fas_Ligand_in_Beta_2002.pdf (725.63 KB)

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