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Evidence that localized variation in primate sequence divergence arises from an influence of nucleosome placement on DNA repair

Date

Authors

Ying, Hua

Epps, Julian

Williams, Rohan

Huttley, Gavin Austin

Publisher

Society for Molecular Biology Evolution

Abstract

Understanding the origins of localized substitution rate heterogeneity has important implications for identifying functional genomic sequences. Outside of gene regions, the origins of rate heterogeneity remain unclear. Experimental studies establish that

Keywords

Keywords: 5 methylcytosine; dinucleotide; DNA; spacer DNA; article; chromatin structure; controlled study; correlation analysis; CpG island; dinucleotide substitution; DNA damage; DNA repair; evolutionary rate; gene mutation; gene sequence; genetic variability; hum 5-methyl-cytosine; Chromatin; Comparative genomics; CpG; Molecular evolution; Nucleosome; Substitution rate heterogeneity

URI

http://hdl.handle.net/1885/39258

Collections

ANU Research Publications

Source

Molecular Biology and Evolution

Type

Journal article

DOI

10.1093/molbev/msp253

Restricted until

2037-12-31

Downloads

File

Description

01_Ying_Evidence_that_localized_2010.pdf (530.19 KB)

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