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Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys

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Date

2007

Authors

Wallace, Bradley A
Ashkan, Keyoumars
Heise, Claire E
Foote, Kelly D.
Torres , Napoleon
Mitrofanis, John
Benabid, Alim-Louis

Journal Title

Journal ISSN

Volume Title

Publisher

Oxford University Press

Abstract

We have examined dopaminergic cell survival after alteration of the subthalamic nucleus (STN) in methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. The STN was lesioned with kainic acid (B series) or underwent deep brain stimulation (DBS)

Description

Keywords

Keywords: 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine; kainic acid; tyrosine 3 monooxygenase; animal experiment; animal model; animal tissue; article; brain depth stimulation; cell count; cell survival; controlled study; dopaminergic activity; excitotoxicity; hist Glutamate toxicity; Kainic acid; Neuroprotection; Parkinson disease; Primate; Substantia nigra

Citation

URI

http://hdl.handle.net/1885/52806

Collections

ANU Research Publications

Source

Brain

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1093/brain/awm137

Restricted until

2037-12-31

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Description
01_Wallace_Survival_of_midbrain_2007.pdf (1.25 MB)

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