Multiple Associated Proteins Regulate Proteasome Structure and Function

Leggett, David S; Hanna, John; Borodovsky, Anna; Crosas, Bernat; Schmidt, Marion; Baker, Rohan; Walz, Thomas; Ploegh, Hidde; Finley, Daniel

Multiple Associated Proteins Regulate Proteasome Structure and Function

Date

2002

Authors

Leggett, David S

Hanna, John

Borodovsky, Anna

Crosas, Bernat

Schmidt, Marion

Baker, Rohan

Walz, Thomas

Ploegh, Hidde

Finley, Daniel

Publisher

Cell Press

Abstract

We have identified proteins that are abundant in affinity-purified proteasomes, but absent from proteasomes as previously defined because elevated salt concentrations dissociate them during purification. The major components are a deubiquitinating enzyme