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Synthesis of thioridazine-VLA-4 antagonist hybrids using N-propargyl northioridazine enantiomers

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dc.contributor.authorMartyn, A. P.
dc.contributor.authorWillis, Anthony
dc.contributor.authorKelso, Michael
dc.date.accessioned2022-07-26T23:43:19Z
dc.date.issued2020
dc.date.updated2021-08-01T08:24:00Z
dc.description.abstractHerein, we report the synthesis of thioridazine-VLA-4 hybrid epimers. These hybrid molecules were obtained by means of a click reaction involving N-propargyl northioridazine enantiomers and an azide containing VLA-4 antagonist. A synthesis of northioridazine enantiomers from racemic thioridazine was developed and the absolute stereochemistry was confirmed by X-ray crystallography. Access to N-substituted thioridazine analogs may reveal that this phenothiazine core has therapeutic potential in other disease avenues.en_AU
dc.description.sponsorshipThis study was supported by the Arrow Bone Marrow Transplant Foundation for their financial support with an Arrow HCC PhD Scholarship.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0039-7911en_AU
dc.identifier.urihttp://hdl.handle.net/1885/269947
dc.language.isoen_AUen_AU
dc.publisherTaylor & Francis Groupen_AU
dc.rights© 2020 Taylor & Francis Group, LLCen_AU
dc.sourceSynthetic Communicationsen_AU
dc.subjectClicken_AU
dc.subjectnorthioridazineen_AU
dc.subjectthioridazineen_AU
dc.subjectVLA-4en_AU
dc.titleSynthesis of thioridazine-VLA-4 antagonist hybrids using N-propargyl northioridazine enantiomersen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue18en_AU
local.bibliographicCitation.lastpage2809en_AU
local.bibliographicCitation.startpage2796en_AU
local.contributor.affiliationMartyn, A. P., University of Wollongongen_AU
local.contributor.affiliationWillis, Anthony, College of Science, ANUen_AU
local.contributor.affiliationKelso, Michael, University of Wollongongen_AU
local.contributor.authoruidWillis, Anthony, u8512028en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor349999 - Other chemical sciences not elsewhere classifieden_AU
local.identifier.ariespublicationa383154xPUB14784en_AU
local.identifier.citationvolume50en_AU
local.identifier.doi10.1080/00397911.2020.1785503en_AU
local.identifier.scopusID2-s2.0-85087633831
local.publisher.urlhttps://www.routledge.com/en_AU
local.type.statusPublished Versionen_AU

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