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Rat model for poly-autoimmunity

Date

Authors

Staykova, Maria

Publisher

Science Publications

Abstract

Around 30% of the male PVG rats have very low testosterone levels. Upon immunisation with myelin basic protein in complete Freund's adjuvant they develop experimental autoimmune encephalomyelitis and adjuvant arthritis. The androgen insensitive syndrome in these rats could be used in studies on poly-autoimmunity as well as in studies on variations in the sexual differentiation of brain and behavior.

Keywords

Keywords: myelin basic protein; testosterone; animal experiment; animal model; arthritis; article; autoimmunity; behavior; controlled study; encephalomyelitis; immunization; male; nonhuman; polyautoimmunity; rat; sex differentiation Adjuvant arthritis; Experimental autoimmune encephalomyelitis; Male PVG rat; Poly-autoimmunity; Sexual behavior

URI

http://hdl.handle.net/1885/70024

Collections

ANU Research Publications

Source

American Journal of Immunology

Type

Journal article

DOI

10.3844/ajisp.2012.84.87

Restricted until

2037-12-31

Downloads

File

Description

01_Staykova_Rat_model_for_2012.pdf (113.05 KB)