Maturation of function in dendritic cells for tolerance and immunity

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dc.contributor.authorQuah, Ben
dc.contributor.authorO'Neill, Helen
dc.date.accessioned2015-12-13T22:48:48Z
dc.date.issued2005
dc.date.updated2015-12-11T10:30:53Z
dc.description.abstractThe capacity of antigen presenting dendritic cells (DC) to function in both tolerance and immunity is now well documented. The function and characteristics of different DC subsets are reviewed here and their capacity to activate T cells under different conditions of maturation and activation is discussed. The immunogenic potential of exosomes produced by DC is also considered in light of evidence that the capacity of exosomes to activate T cells for tolerance or immunity appears to mirror that of the parent DC. A model is proposed whereby exosomes produced by immature DC can function to maintain peripheral tolerance, while exosomes produced by more mature DC can stimulate effector T cells.
dc.identifier.issn1582-1838
dc.identifier.urihttp://hdl.handle.net/1885/80236
dc.publisherFoundation for Cellular and Molecular Medicine
dc.sourceJournal of Cellular and Molecular Medicine
dc.subjectKeywords: animal; cytology; dendritic cell; hematopoietic stem cell; human; immunological tolerance; immunology; innate immunity; review; T lymphocyte; Animals; Dendritic Cells; Hematopoietic Stem Cells; Humans; Immune Tolerance; Immunity, Natural; T-Lymphocytes Dendritic cells; Exosomes; Immunity; Tolerance
dc.titleMaturation of function in dendritic cells for tolerance and immunity
dc.typeJournal article
local.bibliographicCitation.issue3
local.bibliographicCitation.lastpage654
local.bibliographicCitation.startpage643
local.contributor.affiliationQuah, Ben, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationO'Neill, Helen, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidQuah, Ben, u9811290
local.contributor.authoruidO'Neill, Helen, u8100137
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationMigratedxPub8524
local.identifier.citationvolume9
local.identifier.doi10.1111/j.1582-4934.2005.tb00494.x
local.identifier.scopusID2-s2.0-27744482605
local.type.statusPublished Version

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