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Unveiling synaptic plasticity: a new graphical and analytical approach

Date

2000

Authors

Clements, John D
Silver, R Angus

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

Short-term synaptic plasticity has a key role in information processing in the CNS, whereas memories can be formed through long-lasting changes in synaptic strength. Despite the importance of these phenomena, it remains difficult to determine whether a synaptic modulation is expressed at a presynaptic or postsynaptic site. This article describes a new approach that, in its simplest form, can identify the site of expression by direct graphical means. A more-sophisticated form of the technique can quantify functional synaptic properties and determine which of these properties is altered following a modulation of synaptic strength.

Description

Keywords

Keywords: central nervous system; information processing; mathematical analysis; memory; nerve cell plasticity; postsynaptic membrane; presynaptic membrane; priority journal; review; statistical analysis; synapse; technique; variance; 6-Cyano-7-nitroquinoxaline-2,3

Citation

Source

Trends in Neurosciences

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/S0166-2236(99)01520-9

Restricted until

2037-12-31