Probing for the pharmacophore of the cytotoxic neoclerodane salvileucalin B

Heinrich, Nora; Banwell, Martin; Willis, Anthony; Cade, Ian; Capon, Robert J; Huang, Xiao-Cong

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Probing for the pharmacophore of the cytotoxic neoclerodane salvileucalin B

Date

2012

Authors

Heinrich, Nora

Banwell, Martin

Willis, Anthony

Cade, Ian

Capon, Robert J

Huang, Xiao-Cong

Publisher

CSIRO Publishing

Abstract

The novel [4.3.1]propelladiene 2, which embodies the key structural elements of the pentacyclic core of the cytotoxic neoclerodane salvileucalin B (1), has been prepared using a rhodium-catalysed intramolecular Bchner reaction as the key step. Compound 2