Form-Deprivation and Lens-Induced Myopia Are Similarly Affected by Pharmacological Manipulation of the Dopaminergic System in Chicks

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dc.contributor.authorThomson, Kate
dc.contributor.authorKarouta, Cindy
dc.contributor.authorAshby, Regan
dc.date.accessioned2021-03-19T00:43:26Z
dc.date.available2021-03-19T00:43:26Z
dc.date.issued2020
dc.date.updated2020-11-22T07:18:56Z
dc.description.abstractPurpose: Animal models have demonstrated a link between decreases in retinal dopamine levels and the development of form-deprivation myopia (FDM). However, the consistency of dopamine's role in the other major form of experimental myopia, that of lens-induced myopia (LIM), is less clear, raising the question as to what extent dopamine plays a role in human myopia. Therefore, to better define the role of dopamine in both forms of experimental myopia, we examined how consistent the protection afforded by dopamine and the dopamine agonist 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol hydrobromide (ADTN) is between FDM and LIM. Methods: Intravitreal injections of dopamine (0.002, 0.015, 0.150, 1.500 µmol) or ADTN (0.001, 0.010, 0.100, 1.000 µmol) were administered daily to chicks developing FDM or LIM. Axial length and refraction were measured following 4 days of treatment. To determine the receptor subtype by which dopamine and ADTN inhibit FDM and LIM, both compounds were coadministered with either the dopamine D2-like antagonist spiperone (0.005 µmol) or the D1-like antagonist SCH-23390 (0.005 µmol). Results: Intravitreal administration of dopamine or ADTN inhibited the development of FDM (ED50 = 0.003 µmol and ED50 = 0.011 µmol, respectively) and LIM (ED50 = 0.002 µmol and ED50 = 0.010 µmol, respectively) in a dose-dependent manner, with a similar degree of protection observed in both paradigms (P = 0.471 and P = 0.969, respectively). Coadministration with spiperone, but not SCH-23390, inhibited the protective effects of dopamine and ADTN against the development of both FDM (P = 0.214 and P = 0.138, respectively) and LIM (P = 0.116 and P = 0.100, respectively). Conclusions: pharmacological targeting of the retinal dopamine system inhibits FDM and LIM in a similar dose-dependent manner through a D2-like mechanism.en_AU
dc.description.sponsorshipPartially funded by ANU Connect Ventures through a Discovery Translation Fund grant (Project ID: DTF311).en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1552-5783en_AU
dc.identifier.urihttp://hdl.handle.net/1885/227561
dc.language.isoen_AUen_AU
dc.provenanceThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licenseen_AU
dc.publisherAssociation for Research in Vision and Opthalmologyen_AU
dc.rightsCopyright 2020 The Authorsen_AU
dc.rights.licenseCreative Commons Attribution License (CC BY)en_AU
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceInvestigative Ophthalmology and Visual Scienceen_AU
dc.source.urihttps://iovs.arvojournals.org/article.aspx?articleid=2770875en_AU
dc.titleForm-Deprivation and Lens-Induced Myopia Are Similarly Affected by Pharmacological Manipulation of the Dopaminergic System in Chicksen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue12en_AU
local.bibliographicCitation.lastpage13en_AU
local.bibliographicCitation.startpage1en_AU
local.contributor.affiliationThomson, Kate, University of Canberraen_AU
local.contributor.affiliationKarouta, Cindy, University of Canberraen_AU
local.contributor.affiliationAshby, Regan, College of Science, ANUen_AU
local.contributor.authoremailu2532493@anu.edu.auen_AU
local.contributor.authoruidAshby, Regan, u2532493en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor111303 - Vision Scienceen_AU
local.identifier.absfor111502 - Clinical Pharmacology and Therapeuticsen_AU
local.identifier.absseo920502 - Health Related to Ageingen_AU
local.identifier.absseo920107 - Hearing, Vision, Speech and Their Disordersen_AU
local.identifier.ariespublicationa383154xPUB13900en_AU
local.identifier.citationvolume61en_AU
local.identifier.doi10.1167/iovs.61.12.4en_AU
local.identifier.scopusID2-s2.0-85092679097
local.identifier.uidSubmittedBya383154en_AU
local.publisher.urlhttps://iovs.arvojournals.orgen_AU
local.type.statusPublished Versionen_AU

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