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Cytotoxic T cells are the predominant players providing cross-protective immunity induced by {gamma}-irradiated influenza A viruses

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Date

2010

Authors

Furuya, Yoichi
Chan, Jennifer
Regner, Matthias
Lobigs, Mario
Koskinen, Aulikki
Kok, Tuckweng
Manavis, Jim
Li, Peng
Mullbacher, Arno
Alsharifi, Mohammed

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Microbiology

Abstract

We previously demonstrated that a single dose of nonadjuvanted intranasal γ-irradiated influenza A virus can provide robust protection in mice against both homologous and heterosubtypic challenges, including challenge with an H5N1 avian virus strain. We

Description

Keywords

Keywords: perforin; adaptive immunity; adoptive transfer; animal cell; animal cell culture; animal experiment; article; Bagg albino mouse; CD4+ T lymphocyte; CD8+ T lymphocyte; controlled study; cytotoxic T lymphocyte; gamma irradiation; Influenza virus A; Influenz

Citation

URI

http://hdl.handle.net/1885/39374

Collections

ANU Research Publications

Source

Journal of Virology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1128/JVI.02508-09

Restricted until

2037-12-31

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Description
01_Furuya_Cytotoxic_T_cells_are_the_2010.pdf (1.89 MB)

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