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Why do women have more white matter hyperintensities? Sex differences in the extent, aetiology and consequences of leukoaraiosis

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Sachdev, Perminder
Parslow, Ruth
Wen, Wei
Easteal, Simon
Anstey, Kaarin

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BioMed Central

Abstract

Unlike other age-related brain changes, white matter hyperintensities (WMHs) are reported to be more severe in older women than men. This study examined a large epidemiological sample of middle-aged individuals to determine sex differences in WMHs, and investigated their differential functional consequences and aetiological factors to explain the sex differences.

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Annals of General Psychiatry

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