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Designing a C84 fullerene as a specific voltage-gated sodium channel blocker

Date

Authors

Hilder, Tamsyn

Chung, Shin-Ho

Publisher

Springer Verlag

Abstract

Fullerene derivatives demonstrate considerable potential for numerous biological applications, such as the effective inhibition of HIV protease. Recently, they were identified for their ability to indiscriminately block biological ion channels. A fulleren

Keywords

Keywords: Binding; Biological applications; Biological ion channels; Fullerene derivative; Molecular dynamics simulations; Sodium channel; Sodium channel blockers; Voltage-gated potassium channels; Amino acids; Diseases; Ions; Mammals; Molecular dynamics; Fullerene Bacterial voltage-gated sodium channel NavAb; Binding; C84 fullerene derivative; Molecular dynamics; Voltage-gated potassium channel Kv1.3

URI

http://hdl.handle.net/1885/84685

Collections

ANU Research Publications

Source

Nanoscale Research Letters

Type

Journal article

Access Statement

Open Access

DOI

10.1186/1556-276X-8-323

Downloads

File

Description

01_Hilder_Designing_a_C84_fullerene_as_a_2013.pdf (669.52 KB)

02_Hilder_Designing_a_C84_fullerene_as_a_2013.pdf (626.17 KB)