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Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis

Date

Authors

Larter, Claire

Yeh, Matthew

Van Rooyen, Derrick

Brooling, John

Ghatora, Kamaljit

Farrell, Geoffrey

Publisher

Blackwell Publishing Ltd

Abstract

Background and Aims: Lipid accumulation precedes hepatocellular injury and liver inflammation in non-alcoholic steatohepatitis (NASH). The peroxisome proliferator-activated receptor (PPAR)α regulates hepatic lipid disposal. We studied whether pharmacolog

Keywords

Keywords: adiponectin; alanine aminotransferase; cholesterol; fatty acid synthase; immunoglobulin enhancer binding protein; insulin; leptin; messenger RNA; monocyte chemotactic protein 1; peroxisome proliferator activated receptor alpha; pirinixic acid; sterol regu Adipose tissue; Experimental; Inflammation; Monocyte chemoattractant protein 1; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis experimental; Peroxisome proliferator activated receptor alpha; Steatosis

URI

http://hdl.handle.net/1885/38913

Collections

ANU Research Publications

Source

Journal of Gastroenterology and Hepatology

Type

Journal article

DOI

10.1111/j.1440-1746.2011.06939.x

Restricted until

2037-12-31

Downloads

File

Description

01_Larter_Peroxisome_2012.pdf (1.3 MB)