Chemoenzymatic syntheses of the linear triquinane-type sesquiterpenes (+)-hirsutic acid and (-)-complicatic acid
Date
2006
Authors
Jackson, Kerrie
Banwell, Martin
Harfoot, Gwion
Willis, Anthony
Journal Title
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Volume Title
Publisher
Elsevier
Abstract
Formal total syntheses of the natural enantiomeric forms of the title sesquiterpenes 1 and 2 have been achieved using, as starting material, the readily available and enantiomerically pure cis-1,2-dihydrocatechol 4 derived from the whole-cell biotransformation of toluene.
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Keywords
Keywords: complicatic acid; hirsutene; hirsutic acid; sesquiterpene derivative; toluene; unclassified drug; article; biotransformation; chemical modification; enantiomer; enzyme synthesis; reaction analysis; Betulaceae (-)-Complicatic acid; Chemoenzymatic; cis-1,2-Dihydrocatechol; Diels-Alder reaction; Sesquiterpene; Triquinane
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Tetrahedron Letters
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Journal article
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2037-12-31
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