Practical considerations regarding the use of genotype and pedigree data to model relatedness in the context of genome-wide association studies

Cheng, Riyan; Parker , Clarissa C; Abney, Mark; Palmer, Abraham A

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Practical considerations regarding the use of genotype and pedigree data to model relatedness in the context of genome-wide association studies

Date

2013

Authors

Cheng, Riyan

Parker , Clarissa C

Abney, Mark

Palmer, Abraham A

Publisher

Genetics Society of America

Abstract

Genome-wide association studies of complex traits often are complicated by relatedness among individuals. Ignoring or inappropriately accounting for relatedness often results in inflated type I error rates. Either genotype or pedigree data can be used to