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Recent Advances in Ion Channel Research

Date

Authors

Chung, Shin-Ho

Kuyucak, Serdar

Publisher

Elsevier

Abstract

The field of ion channels has entered into a rapid phase of development in the last few years, partly due to the breakthroughs in determination of the crystal structures of membrane proteins and advances in computer simulations of biomolecules. These advances have finally enabled the long-dreamed goal of relating function of a channel to its underlying molecular structure. Here we present simplified accounts of the competing permeation theories and then discuss their application to the potassium, gramicidin A and calcium channels.

Keywords

Keywords: calcium channel; calcium channel L type; calcium ion; gramicidin A; ion channel; membrane protein; potassium channel; sodium ion; calculation; computer simulation; crystal structure; crystallization; geometry; ion permeability; molecular dynamics; molecul Brownian dynamics; Channel modeling; Membrane ion channel; Molecular dynamics; Theories of ion permeation

URI

http://hdl.handle.net/1885/71612

Collections

ANU Research Publications

Source

Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics

Type

Journal article

DOI

10.1016/S0005-2736(02)00574-6

Restricted until

2037-12-31

Downloads

File

Description

01_Chung_Recent_Advances_in_Ion_Channel_2002.pdf (381.29 KB)