Punctate inner choroidopathy: Clinical features and outcomes

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dc.contributor.authorEssex, Rohan
dc.contributor.authorWong, James
dc.contributor.authorFraser-Bell, Samantha
dc.contributor.authorSandback, Jen
dc.contributor.authorTufail, Adnan
dc.contributor.authorBird, Alan
dc.contributor.authorDowler, Jonathan
dc.date.accessioned2015-12-10T23:03:11Z
dc.date.issued2010
dc.date.updated2016-02-24T08:31:20Z
dc.description.abstractObjective: To describe the clinical features and outcomes of a large group of patients with a spectrum of clinical appearances and diagnosed as having punctate inner choroidopathy (PIC). Methods: In a retrospective consecutive case series, patients seen during a 16-year period at Moorfields EyeHospital who were diagnosed as having PIC and had a minimum of 12 months' follow-up were included. Patients were classified as having typical PIC or atypical PIC (larger, presumed ocular histoplasmosis syndrome - like lesions). Main outcome measures included development of choroidal neovascularization, development of new PIC lesions, and final visual acuity. Results: A total of 136 patients (271 eyes) were included. The average age was 32 years, 126 patients (93%) were female, and the mean refraction was -4.6 diopters. The overall mean follow-up was 6.2 years. Among 63 normal fellow eyes, 56 (88%) remained unchanged, 3 (5%) developed PIC lesions, and 4 (6%) developed choroidal neovascularization. Eyes with PIC lesions remained unchanged in 49 of 74 cases (66%), with 9 (12%) developing new PIC lesions and 16 (22%) developing choroidal neovascular membrane. In eyes with choroidal neovascularization, the mean logMAR visual acuity was 0.63 at study entry, 0.63 at 12 months, 0.61 at 2 years, and 0.71 at final review (mean, 6.1 years). Overall, 40 eyes with PIC-related choroidal neovascular membrane (26%) had final visual acuity less than 6/60. No differences were observed between typical and atypical PIC eyes in any of the outcome measures or in any of the subgroup analyses. Conclusions: Punctate inner choroidopathy - related choroidal neovascularization was not visually benign. No differences were observed between eyes with typical and atypical choroidal lesions, supporting the notion that they represent a spectrum of a single disease, PIC.
dc.identifier.issn0003-9950
dc.identifier.urihttp://hdl.handle.net/1885/62058
dc.publisherAmerican Medical Association
dc.sourceArchives of Ophthalmology
dc.subjectKeywords: adolescent; adult; aged; article; chorioretinopathy; clinical feature; disease course; female; human; major clinical study; male; ophthalmoscopy; priority journal; punctate inner choroidopathy; retrospective study; subretinal neovascularization; visual ac
dc.titlePunctate inner choroidopathy: Clinical features and outcomes
dc.typeJournal article
local.bibliographicCitation.issue8
local.bibliographicCitation.lastpage987
local.bibliographicCitation.startpage982
local.contributor.affiliationEssex, Rohan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWong, James, Institute of Opthalomogy
local.contributor.affiliationFraser-Bell, Samantha, Institute of Opthalomogy
local.contributor.affiliationSandback, Jen, Institute of Opthalomogy
local.contributor.affiliationTufail, Adnan, Institute of Opthalomogy
local.contributor.affiliationBird, Alan, Institute of Opthalomogy
local.contributor.affiliationDowler, Jonathan, Institute of Opthalomogy
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidEssex, Rohan, a274304
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor111399 - Optometry and Ophthalmology not elsewhere classified
local.identifier.ariespublicationf2965xPUB664
local.identifier.citationvolume128
local.identifier.doi10.1001/archophthalmol.2010.157
local.identifier.scopusID2-s2.0-77955443538
local.identifier.uidSubmittedByf2965
local.type.statusPublished Version

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