Non-oxidized cellulose nanofibers as a topical hemostat: In vitro thromboelastometry studies of structure vs function
dc.contributor.author | Mohamed, Elmira | |
dc.contributor.author | Coupland, Lucy | |
dc.contributor.author | Crispin, Philip | |
dc.contributor.author | Fitzgerald, Ailene | |
dc.contributor.author | Nisbet, David | |
dc.contributor.author | Tsuzuki, Takuya | |
dc.date.accessioned | 2022-10-31T00:33:01Z | |
dc.date.issued | 2021 | |
dc.date.updated | 2021-11-28T07:25:34Z | |
dc.description.abstract | Hemorrhage remains a significant cause of morbidity and mortality following trauma and during complex surgeries. A variety of nanomaterials, including oxidized cellulose nanofibers (OCNFs), have been studied to overcome the disadvantages of current commercial topical hemostats. However, the relationship between nano-structural characteristics and hemostatic efficacy of non-oxidized cellulose nanofibers (CNFs) has not been elucidated. Herein, we present the first report of the correlation between structure and hemostatic performance of CNFs. In vitro thromboelastometry studies on CNFs, synthesized by ball-milling, showed that there is an optimum balance point between the aspect ratio (AR) and specific surface area (SSA) of nanofibers in terms of their maximum contribution to platelet function and plasma coagulation. The optimized CNFs with high SSA (17 m2/g) and a high AR (166) shortened normal whole blood clotting time by 68%, outperforming cellulose-based hemostats. Additionally, CNFs reduced clotting time in platelet-deficient blood (by 80%) and heparinized blood (by 54%) | en_AU |
dc.format.mimetype | application/pdf | en_AU |
dc.identifier.issn | 0144-8617 | en_AU |
dc.identifier.uri | http://hdl.handle.net/1885/276780 | |
dc.language.iso | en_AU | en_AU |
dc.publisher | Pergamon-Elsevier Ltd | en_AU |
dc.rights | © 2021 Elsevier Ltd. | en_AU |
dc.source | Carbohydrate Polymers | en_AU |
dc.subject | Non-oxidized cellulose nanofibers | en_AU |
dc.subject | Ball-milling | en_AU |
dc.subject | Green hemostatic material | en_AU |
dc.subject | Blood-material interaction | en_AU |
dc.subject | In vitro thromboelastometry | en_AU |
dc.title | Non-oxidized cellulose nanofibers as a topical hemostat: In vitro thromboelastometry studies of structure vs function | en_AU |
dc.type | Journal article | en_AU |
local.bibliographicCitation.lastpage | 9 | en_AU |
local.bibliographicCitation.startpage | 1 | en_AU |
local.contributor.affiliation | Mohamed, Elmira, OTH Other Departments, ANU | en_AU |
local.contributor.affiliation | Coupland, Lucy, College of Health and Medicine, ANU | en_AU |
local.contributor.affiliation | Crispin, Philip, College of Health and Medicine, ANU | en_AU |
local.contributor.affiliation | Fitzgerald, Ailene, The Canberra Hospital | en_AU |
local.contributor.affiliation | Nisbet, David, College of Health and Medicine, ANU | en_AU |
local.contributor.affiliation | Tsuzuki, Takuya, College of Engineering and Computer Science, ANU | en_AU |
local.contributor.authoremail | u5031428@anu.edu.au | en_AU |
local.contributor.authoruid | Mohamed, Elmira, u5941909 | en_AU |
local.contributor.authoruid | Coupland, Lucy, u3562509 | en_AU |
local.contributor.authoruid | Crispin, Philip, u5115694 | en_AU |
local.contributor.authoruid | Nisbet, David, u5031428 | en_AU |
local.contributor.authoruid | Tsuzuki, Takuya, u5313438 | en_AU |
local.description.embargo | 2099-12-31 | |
local.description.notes | Imported from ARIES | en_AU |
local.identifier.absfor | 320903 - Central nervous system | en_AU |
local.identifier.absfor | 310113 - Synthetic biology | en_AU |
local.identifier.absfor | 310102 - Cell development, proliferation and death | en_AU |
local.identifier.absseo | 200105 - Treatment of human diseases and conditions | en_AU |
local.identifier.absseo | 280105 - Expanding knowledge in the chemical sciences | en_AU |
local.identifier.absseo | 280102 - Expanding knowledge in the biological sciences | en_AU |
local.identifier.ariespublication | a383154xPUB19183 | en_AU |
local.identifier.citationvolume | 265 | en_AU |
local.identifier.doi | 10.1016/j.carbpol.2021.118043 | en_AU |
local.identifier.scopusID | 2-s2.0-85104390066 | |
local.identifier.uidSubmittedBy | a383154 | en_AU |
local.publisher.url | https://www.elsevier.com/en-au | en_AU |
local.type.status | Published Version | en_AU |
Downloads
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- 1-s2.0-S0144861721004306-main.pdf
- Size:
- 4.59 MB
- Format:
- Adobe Portable Document Format
- Description: