NMR Structure of  Citrobacter freundii  AmpD, Comparison with Bacteriophage T7 Lysozyme and Homology with PGRP Domains

Liepinsh, Edvards; Gastaud, J.; Dehareng, Dominique; Joris, Bernard; Otting, Gottfried

NMR Structure of Citrobacter freundii AmpD, Comparison with Bacteriophage T7 Lysozyme and Homology with PGRP Domains

Date

2003

Authors

Liepinsh, Edvards

Gastaud, J.

Dehareng, Dominique

Joris, Bernard

Otting, Gottfried

Publisher

Elsevier

Abstract

AmpD is a bacterial amidase involved in the recycling of cell-wall fragments in Gram-negative bacteria. Inactivation of AmpD leads to derepression of β-lactamase expression, presenting a major pathway for the acquisition of constitutive antibiotic resist