Life event stress and chronic obstructive pulmonary disease (COPD): associations with mental well-being and quality of life in a population-based study

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dc.contributor.authorLu, Yanxia
dc.contributor.authorNyunt, Ma Shwe Zin
dc.contributor.authorGwee, Xinyi
dc.contributor.authorFeng, Liang
dc.contributor.authorFeng, Lei
dc.contributor.authorKua, Ee Heok
dc.contributor.authorKumar, Rajeev
dc.contributor.authorNg, Tze Pin
dc.date.accessioned2015-12-09T04:16:39Z
dc.date.available2015-12-09T04:16:39Z
dc.date.issued2012-11-19
dc.date.updated2016-02-24T09:03:43Z
dc.description.abstractOBJECTIVES To investigate whether life event stress was associated with greater psychological distress and poorer quality of life in older individuals with chronic obstructive pulmonary disease (COPD), in comparison with their counterparts without COPD. DESIGN Cross-sectional study. PARTICIPANTS A population-based sample (N=497) of individuals aged 65 and above with COPD (postbronchodilatation FEV1/FVC<0.70, N=136) and without COPD (N=277). MEASUREMENTS We measured life event stress, depressive symptoms (GDS, Geriatric Depression Scale), cognitive symptoms and function (CFQ, Cognitive Failures Questionnaire and MMSE, Mini-Mental State Examination), and physical and mental health functional status (SF36-PCS, Physical Health Component Summary and SF36-MCS, Mental Health Component Summary) in participants with and without COPD. RESULTS In two-way analysis of variance controlling for potential confounders, life event stress was associated with significant main effects of worse GDS (p<0.001), SF36-PCS (p=0.008) and SF36-MCS scores (p<0.001), and with significant interaction effects on GDS score (p<0.001), SF36-PCS (p=0.045) and SF36-MCS (p=0.034) in participants with COPD, more than in non-COPD participants. The main effect of COPD was found for postbronchodilator FEV1 (p<0.001) and cognitive symptoms (p=0.02). CONCLUSIONS Our findings indicate that life event stress was associated with more depressive symptoms and worse quality of life in individuals with COPD, much more than in those without COPD. Further studies should explore the role of cognitive appraisal of stress, coping resources and psycho-social support in this relationship.
dc.description.sponsorshipThe study is supported by a research grant (No 03/1/21/17/214) from the Biomedical Research Council, Agency for Science, Technology and Research (ASTAR).en_AU
dc.identifier.issn2044-6055en_AU
dc.identifier.urihttp://hdl.handle.net/1885/38454
dc.publisherBMJ Publishing Group
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
dc.sourceBMJ Open
dc.source.urihttp://bmjopen.bmj.com/content/2/6/e001674.fullen_AU
dc.subjectKeywords: bronchodilating agent; aged; article; chronic obstructive lung disease; cognition; cohort analysis; cross-sectional study; distress syndrome; female; forced expiratory volume; forced vital capacity; Geriatric Depression Scale; human; life event; life stre
dc.titleLife event stress and chronic obstructive pulmonary disease (COPD): associations with mental well-being and quality of life in a population-based study
dc.typeJournal article
local.bibliographicCitation.issue6en_AU
local.bibliographicCitation.lastpagee001674en_AU
local.bibliographicCitation.startpagee001674en_AU
local.contributor.affiliationLu, Yanxia, National University of Singapore, Singaporeen_AU
local.contributor.affiliationNyunt, Ma Shwe Zin, National University Hospital, Singaporeen_AU
local.contributor.affiliationGwee, Xinyi, National University of Singapore, Singaporeen_AU
local.contributor.affiliationFeng, Liang, National University of Singapore, Singaporeen_AU
local.contributor.affiliationFeng, Lei, National University of Singapore, Singaporeen_AU
local.contributor.affiliationKua, Ee Heok, National University of Singapore, Singaporeen_AU
local.contributor.affiliationKumar, Rajeev, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National Universityen_AU
local.contributor.affiliationNg, Tze Pin, National University Hospital, Singaporeen_AU
local.contributor.authoremailRajeev.Kumar@act.gov.auen_AU
local.contributor.authoremailpcmngtp@nus.edu.sgen_AU
local.contributor.authoruidKumar, Rajeev, u3923137en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor110319en_AU
local.identifier.ariespublicationf5625xPUB2909en_AU
local.identifier.citationvolume2en_AU
local.identifier.doi10.1136/bmjopen-2012-001674en_AU
local.identifier.essn2044-6055en_AU
local.identifier.scopusID2-s2.0-84873822935
local.identifier.thomsonID000315081400080
local.identifier.uidSubmittedByu3488905en_AU
local.publisher.urlhttp://bmjopen.bmj.com/en_AU
local.type.statusPublished Versionen_AU

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